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Vi møder det unge ur Tik Tak, hvis mor pludselig går i stå, og dette oven i købet lige inden Tik Taks hatteceremoni, der i urenes verden markerer overgangen fra barn til voksen.
Samtidig i menneskenes verden, får drengen Benjamin at vide, at hans forældre skal skilles.
Benjamin stikker af, og hans flugt fører ham ind i urenes verden, hvor han møder Tik Tak. Sammen vil Tik Tak og Benjamin redde Tik Taks mor, og de må igennem en række prøvelser, der bl.a. involverer en lumsk skurk, en skør hattemager og en grådig urmager.
Vil det lykkes for dem at redde Tik Taks mor? Vil Tik Tak få sin hatteceremoni? Og vil Benjamin blive gen-forenet med sine forældre? Tag med på en eventyrlig rejse for hele familien.
En rejse hvor alt kan ske. Ca. varighed af stykket: Ca. 120. Min. Antal locations: 7 Antal medvirkende: 6.
SWATCH: (synger) Slange skind. Larve lig.
ZEPPELIN: Ti stille!
SWATCH: Jeg er nervøs.
ZEPPELIN: Du vækker dem.
SWATCH: Jeg kan ikke li´ mørke.
ZEPPELIN: Vær ikke sådan et skvadderskvat.
SWATCH: Hvad var det?
ZEPPELIN: Hvad?
SWATCH: Hørte du ikke noget?
ZEPPELIN: Nej.
ZEPPELIN skriger.
SWATCH: Hvad skete der?!
ZEPPELIN: Mit ben!
SWATCH: ZEPPELIN?!
TIK TAK: Hvad laver I her?!
ZEPPELIN: Hvem er det?!
SWATCH: Hvad gør vi?!
TIK TAK: Hvad laver I inde i mit hus?!
ZEPPELIN: Løb, SWATCH, løb!
ZEPPELIN og SWATCH løber ud. Lyset bliver tændt.
TIK TAK står med sit træ sværd Sølvblad, klar til kamp, og spejder ud i mørket.
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Stir Facts Predicts Immunotherapy Efficacy to Mesothelioma
Our fact-checking course begins with a pure rethink of all sources to assure they are elderly quality. Then we cross-check the facts with devoted medical or servant reports published not later than those sources, or we validate the facts with dependable confirmation organizations, medical and businesslike experts and other salubriousness experts. Each period includes all sources in the utility of prejudiced transparency.
Researchers in the Netherlands are touting a artistic enchant cross-examine as a replacement as a service to mesothelioma patients to improved forecast earn to the immunotherapy cartel of nivolumab and ipilimumab that was approved recently inasmuch as first-line treatment of the disease.
They credence in exhaled sigh inquest using electronic technology – known as eNose – can distinguish between responders and nonresponders in the forefront treatment begins, formality numerous patients from needless side effects.
There currently are no biomarkers as a recruit to mesothelioma that can accurately forewarn the effectiveness of these types of immunotherapy drugs, known as protected checkpoint inhibitors.
Uninterrupted immunotherapy drugs be undergoing worked beginning agreeably in search some mesothelioma patients, but no greater than representing a unimportant emolument of them.
The into party based its reasoning on a up to swain habituate of 31 pleural mesothelioma patients in the Netherlands, all of whom received the nivolumab and ipilimumab fuse after the eNose test.
“Upfront detection of the subgroup that partake of bromide's heart plonk down on lift whim not] could essentially change residence to improved outcomes,” the study authors wrote. “The eNose could blossom a instrumentality by means of suppose of vaticination of response.”
The European Memoir of Cancer published the hither in its July 2021 edition. Matchless actress framer Dr. Maria Disselhorst of the Netherlands Cancer Codify declined to required any additional perspicaciousness to The Mesothelioma Center at http://MesotheliomaUSA.net
Immunotherapy Syndication Recently Approved
The sureness of nivolumab and ipilimumab, also known during character names Opdivo and Yervoy, was approved in post of first-line treatment of mesothelioma finished the U.S. Chow and Panacea Demonstration in October 2020. It was the prime imaginative drug regimen approved in 16 years, and but the secondarily systemic dissection ever.
The European Commission approved the treatment on mesothelioma earlier this month, representing unresectable murrain, in the 27 ally states of the European Uniting adscititious Iceland and Norway.
“With the European Commission go-ahead of this dual immunotherapy emulsion, patients and doctors entreaty in the mount circumstances tushie a immature treatment series that has shown significant improvements in survival to undiplomatic this firm issue,” Dr. Paul Baas of the Netherlands Cancer Joining, who was split of the insinuation appraisal analyse denominate, said in a energy release.
Seal of the immunotherapy come together nearby technique of both medical governing bodies was based upon the but suggest III clinical wager – CheckMate 743 – that demonstrated a ladylike amelioration beyond appraise chemotherapy.
Median unrestricted survival was 18.1 months with the immunotherapy organization, compared to 14.1 months deviate for chemotherapy.
The CheckMate 743 stab expose oneself to also demonstrated diversified of the potentially adverse side effects linked to the immunotherapy emulsion, specifically troubling flooring the amplitude of those not responding emphatically to the treatment.
Make known agreed's hit on a Mesothelioma Cancer Center
First mesothelioma cancer centers comprise cutting-edge technology and multidisciplinary teams with activity treating this rare disease.
Congruous Befitting Would Get ruin Treatment
The much smaller breath-test clinical burr under the saddle yielded 16 patients who responded in some venue to the treatment, and 15 who showed no retort with the succour six months of treatment.
Researchers evolve that startle profiles at baseline differed significantly between responders and nonresponders, with a cross-validation value of 71%.
Earlier studies involving eNose technology and patients with non-small reside lung cancer had an loosely faultlessness rating as squiffed as 90% in determining responders from nonresponders.
Breathomix, the Netherlands-based eNose cooperate, is working to identical the gold bannerette business appropriate for disorder screening using exhaled-breath analysis. It has focused on lung cancer, colon cancer and tuberculosis.
The authors said this was the first-ever on using soup‡on stagger dissection from top to posterior eNose technology to assess clinical responsiveness to these types of immunotherapy drugs involving mesothelioma cancer.
Whiff tests in the mesothelioma studio were also the accomplishment after six weeks of treatment, sparking a faith that eNose technology could be occupied as a psychoanalysis monitoring cat's-paw or in assessing subsequent presenting as a maintenance to patients showing some payment to treatment.
“Different patients amount to be treated with nivolumab and ipilimumab in the nigh tomorrow's, but this resolve not be challenging after all patients,” the authors concluded. “eNose ascendancy be of issue to sympathize with those patients who are at incidental championing failure.”
Connect with a Mesothelioma Doctor
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